Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells
Identifieur interne : 000212 ( Main/Exploration ); précédent : 000211; suivant : 000213Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells
Auteurs : Marie-Eve Tremblay ; Issan Zhang [Canada] ; Kanchan Bisht ; Julie C. Savage ; Cynthia Lecours ; Martin Parent ; Vladimir Titorenko ; Dusica Maysinger [Canada]Source :
- Journal of Neuroinflammation [ 1742-2094 ] ; 2016.
Abstract
Organelle remodeling processes are evolutionarily conserved and involved in cell functions during development, aging, and cell death. Some endogenous and exogenous molecules can modulate these processes. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has mainly been considered as a modulator of plasma membrane fluidity in brain development and aging, while DHA’s role in organelle remodeling in specific neural cell types at the ultrastructural level remains largely unexplored. DHA is notably incorporated into dynamic organelles named lipid bodies (LBs). We hypothesized that DHA could attenuate the inflammatory response in lipopolysaccharide (LPS)-activated microglia by remodeling LBs and altering their functional interplay with mitochondria and other associated organelles.
We used electron microscopy to analyze at high spatial resolution organelle changes in N9 microglial cells exposed to the proinflammogen LPS, with or without DHA supplementation. Our results revealed that DHA reverses several effects of LPS in organelles. In particular, a large number of very small and grouped LBs was exclusively found in microglial cells exposed to DHA. In contrast, LBs in LPS-stimulated cells in the absence of DHA were sparse and large. LBs formed in the presence of DHA were generally electron-dense, suggesting DHA incorporation into these organelles. The accumulation of LBs in microglial cells from mouse and human was confirmed in situ. In addition, DHA induced numerous contacts between LBs and mitochondria and reversed the frequent disruption of mitochondrial integrity observed upon LPS stimulation. Dilation of the endoplasmic reticulum lumen was also infrequent following DHA treatment, suggesting that DHA reduces oxidative stress and protein misfolding. Lipidomic analysis in N9 microglial cells treated with DHA revealed an increase in phosphatidylserine, indicating the role of this phospholipid in normalization and maintenance of physiological membrane functions. This finding was supported by a marked reduction of microglial filopodia and endosome number and significant reduction of LPS-induced phagocytosis.
DHA attenuates the inflammatory response in LPS-stimulated microglial cells by remodeling LBs and altering their interplay with mitochondria and other associated organelles. Our findings point towards a mechanism by which omega-3 DHA participates in organelle reorganization and contributes to the maintenance of neural cell homeostasis.
The online version of this article (doi:10.1186/s12974-016-0580-0) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12974-016-0580-0
PubMed: 27220286
PubMed Central: 4879742
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000258
- to stream Pmc, to step Curation: 000258
- to stream Pmc, to step Checkpoint: 000064
- to stream Ncbi, to step Merge: 001F85
- to stream Ncbi, to step Curation: 001F85
- to stream Ncbi, to step Checkpoint: 001F85
- to stream Main, to step Merge: 000212
- to stream Main, to step Curation: 000212
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells</title><author><name sortKey="Tremblay, Marie Eve" sort="Tremblay, Marie Eve" uniqKey="Tremblay M" first="Marie-Eve" last="Tremblay">Marie-Eve Tremblay</name><affiliation><nlm:aff id="Aff1">Department of Molecular Medicine, Faculty of Medicine, Université Laval, Axe Neurosciences, Centre de recherche du CHU de Québec, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Issan" sort="Zhang, Issan" uniqKey="Zhang I" first="Issan" last="Zhang">Issan Zhang</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Pharmacology and Therapeutics, McGill University, Montréal, QC Canada</nlm:aff><orgName type="university">Université McGill</orgName><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bisht, Kanchan" sort="Bisht, Kanchan" uniqKey="Bisht K" first="Kanchan" last="Bisht">Kanchan Bisht</name><affiliation><nlm:aff id="Aff1">Department of Molecular Medicine, Faculty of Medicine, Université Laval, Axe Neurosciences, Centre de recherche du CHU de Québec, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Savage, Julie C" sort="Savage, Julie C" uniqKey="Savage J" first="Julie C." last="Savage">Julie C. Savage</name><affiliation><nlm:aff id="Aff1">Department of Molecular Medicine, Faculty of Medicine, Université Laval, Axe Neurosciences, Centre de recherche du CHU de Québec, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Lecours, Cynthia" sort="Lecours, Cynthia" uniqKey="Lecours C" first="Cynthia" last="Lecours">Cynthia Lecours</name><affiliation><nlm:aff id="Aff1">Department of Molecular Medicine, Faculty of Medicine, Université Laval, Axe Neurosciences, Centre de recherche du CHU de Québec, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name><affiliation><nlm:aff id="Aff3">Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre de recherche de l’Institut universitaire en santé mentale de Québec, Université Laval, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Titorenko, Vladimir" sort="Titorenko, Vladimir" uniqKey="Titorenko V" first="Vladimir" last="Titorenko">Vladimir Titorenko</name><affiliation><nlm:aff id="Aff4">Department of Biology, Concordia University, Montréal, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Maysinger, Dusica" sort="Maysinger, Dusica" uniqKey="Maysinger D" first="Dusica" last="Maysinger">Dusica Maysinger</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Pharmacology and Therapeutics, McGill University, Montréal, QC Canada</nlm:aff><orgName type="university">Université McGill</orgName><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27220286</idno><idno type="pmc">4879742</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879742</idno><idno type="RBID">PMC:4879742</idno><idno type="doi">10.1186/s12974-016-0580-0</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000258</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000258</idno><idno type="wicri:Area/Pmc/Curation">000258</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000258</idno><idno type="wicri:Area/Pmc/Checkpoint">000064</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000064</idno><idno type="wicri:Area/Ncbi/Merge">001F85</idno><idno type="wicri:Area/Ncbi/Curation">001F85</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F85</idno><idno type="wicri:Area/Main/Merge">000212</idno><idno type="wicri:Area/Main/Curation">000212</idno><idno type="wicri:Area/Main/Exploration">000212</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells</title><author><name sortKey="Tremblay, Marie Eve" sort="Tremblay, Marie Eve" uniqKey="Tremblay M" first="Marie-Eve" last="Tremblay">Marie-Eve Tremblay</name><affiliation><nlm:aff id="Aff1">Department of Molecular Medicine, Faculty of Medicine, Université Laval, Axe Neurosciences, Centre de recherche du CHU de Québec, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Issan" sort="Zhang, Issan" uniqKey="Zhang I" first="Issan" last="Zhang">Issan Zhang</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Pharmacology and Therapeutics, McGill University, Montréal, QC Canada</nlm:aff><orgName type="university">Université McGill</orgName><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bisht, Kanchan" sort="Bisht, Kanchan" uniqKey="Bisht K" first="Kanchan" last="Bisht">Kanchan Bisht</name><affiliation><nlm:aff id="Aff1">Department of Molecular Medicine, Faculty of Medicine, Université Laval, Axe Neurosciences, Centre de recherche du CHU de Québec, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Savage, Julie C" sort="Savage, Julie C" uniqKey="Savage J" first="Julie C." last="Savage">Julie C. Savage</name><affiliation><nlm:aff id="Aff1">Department of Molecular Medicine, Faculty of Medicine, Université Laval, Axe Neurosciences, Centre de recherche du CHU de Québec, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Lecours, Cynthia" sort="Lecours, Cynthia" uniqKey="Lecours C" first="Cynthia" last="Lecours">Cynthia Lecours</name><affiliation><nlm:aff id="Aff1">Department of Molecular Medicine, Faculty of Medicine, Université Laval, Axe Neurosciences, Centre de recherche du CHU de Québec, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name><affiliation><nlm:aff id="Aff3">Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre de recherche de l’Institut universitaire en santé mentale de Québec, Université Laval, Québec, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Titorenko, Vladimir" sort="Titorenko, Vladimir" uniqKey="Titorenko V" first="Vladimir" last="Titorenko">Vladimir Titorenko</name><affiliation><nlm:aff id="Aff4">Department of Biology, Concordia University, Montréal, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Maysinger, Dusica" sort="Maysinger, Dusica" uniqKey="Maysinger D" first="Dusica" last="Maysinger">Dusica Maysinger</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Department of Pharmacology and Therapeutics, McGill University, Montréal, QC Canada</nlm:aff><orgName type="university">Université McGill</orgName><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Neuroinflammation</title><idno type="eISSN">1742-2094</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Organelle remodeling processes are evolutionarily conserved and involved in cell functions during development, aging, and cell death. Some endogenous and exogenous molecules can modulate these processes. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has mainly been considered as a modulator of plasma membrane fluidity in brain development and aging, while DHA’s role in organelle remodeling in specific neural cell types at the ultrastructural level remains largely unexplored. DHA is notably incorporated into dynamic organelles named lipid bodies (LBs). We hypothesized that DHA could attenuate the inflammatory response in lipopolysaccharide (LPS)-activated microglia by remodeling LBs and altering their functional interplay with mitochondria and other associated organelles.</p></sec><sec><title>Results</title><p>We used electron microscopy to analyze at high spatial resolution organelle changes in N9 microglial cells exposed to the proinflammogen LPS, with or without DHA supplementation. Our results revealed that DHA reverses several effects of LPS in organelles. In particular, a large number of very small and grouped LBs was exclusively found in microglial cells exposed to DHA. In contrast, LBs in LPS-stimulated cells in the absence of DHA were sparse and large. LBs formed in the presence of DHA were generally electron-dense, suggesting DHA incorporation into these organelles. The accumulation of LBs in microglial cells from mouse and human was confirmed in situ. In addition, DHA induced numerous contacts between LBs and mitochondria and reversed the frequent disruption of mitochondrial integrity observed upon LPS stimulation. Dilation of the endoplasmic reticulum lumen was also infrequent following DHA treatment, suggesting that DHA reduces oxidative stress and protein misfolding. Lipidomic analysis in N9 microglial cells treated with DHA revealed an increase in phosphatidylserine, indicating the role of this phospholipid in normalization and maintenance of physiological membrane functions. This finding was supported by a marked reduction of microglial filopodia and endosome number and significant reduction of LPS-induced phagocytosis.</p></sec><sec><title>Conclusions</title><p>DHA attenuates the inflammatory response in LPS-stimulated microglial cells by remodeling LBs and altering their interplay with mitochondria and other associated organelles. Our findings point towards a mechanism by which omega-3 DHA participates in organelle reorganization and contributes to the maintenance of neural cell homeostasis.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s12974-016-0580-0) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Joffre, C" uniqKey="Joffre C">C Joffre</name></author><author><name sortKey="Nadjar, A" uniqKey="Nadjar A">A Nadjar</name></author><author><name sortKey="Lebbadi, M" uniqKey="Lebbadi M">M Lebbadi</name></author><author><name sortKey="Calon, F" uniqKey="Calon F">F Calon</name></author><author><name sortKey="Laye, S" uniqKey="Laye S">S Laye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bazan, Ng" uniqKey="Bazan N">NG Bazan</name></author><author><name sortKey="Molina, Mf" uniqKey="Molina M">MF Molina</name></author><author><name sortKey="Gordon, Wc" uniqKey="Gordon W">WC Gordon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, Dj" uniqKey="Murphy D">DJ Murphy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Calder, Pc" uniqKey="Calder P">PC Calder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palacios Pelaez, R" uniqKey="Palacios Pelaez R">R Palacios-Pelaez</name></author><author><name sortKey="Lukiw, Wj" uniqKey="Lukiw W">WJ Lukiw</name></author><author><name sortKey="Bazan, Ng" uniqKey="Bazan N">NG Bazan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casali, Bt" uniqKey="Casali B">BT Casali</name></author><author><name sortKey="Corona, Aw" uniqKey="Corona A">AW Corona</name></author><author><name sortKey="Mariani, Mm" uniqKey="Mariani M">MM Mariani</name></author><author><name sortKey="Karlo, Jc" uniqKey="Karlo J">JC Karlo</name></author><author><name sortKey="Ghosal, K" uniqKey="Ghosal K">K Ghosal</name></author><author><name sortKey="Landreth, Ge" uniqKey="Landreth G">GE Landreth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serhan, Cn" uniqKey="Serhan C">CN Serhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serhan, Cn" uniqKey="Serhan C">CN Serhan</name></author><author><name sortKey="Dalli, J" uniqKey="Dalli J">J Dalli</name></author><author><name sortKey="Colas, Ra" uniqKey="Colas R">RA Colas</name></author><author><name sortKey="Winkler, Jw" uniqKey="Winkler J">JW Winkler</name></author><author><name sortKey="Chiang, N" uniqKey="Chiang N">N Chiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnoux, I" uniqKey="Arnoux I">I Arnoux</name></author><author><name sortKey="Audinat, E" uniqKey="Audinat E">E Audinat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bazan, Ng" uniqKey="Bazan N">NG Bazan</name></author><author><name sortKey="Musto, Ae" uniqKey="Musto A">AE Musto</name></author><author><name sortKey="Knott, Ej" uniqKey="Knott E">EJ Knott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yurko Mauro, K" uniqKey="Yurko Mauro K">K Yurko-Mauro</name></author><author><name sortKey="Alexander, Dd" uniqKey="Alexander D">DD Alexander</name></author><author><name sortKey="Van Elswyk, Me" uniqKey="Van Elswyk M">ME Van Elswyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farese, Rv" uniqKey="Farese R">RV Farese</name></author><author><name sortKey="Walther, Tc" uniqKey="Walther T">TC Walther</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodman, Jm" uniqKey="Goodman J">JM Goodman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujimoto, T" uniqKey="Fujimoto T">T Fujimoto</name></author><author><name sortKey="Parton, Rg" uniqKey="Parton R">RG Parton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujimoto, T" uniqKey="Fujimoto T">T Fujimoto</name></author><author><name sortKey="Ohsaki, Y" uniqKey="Ohsaki Y">Y Ohsaki</name></author><author><name sortKey="Cheng, J" uniqKey="Cheng J">J Cheng</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author><author><name sortKey="Shinohara, Y" uniqKey="Shinohara Y">Y Shinohara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tauchi Sato, K" uniqKey="Tauchi Sato K">K Tauchi-Sato</name></author><author><name sortKey="Ozeki, S" uniqKey="Ozeki S">S Ozeki</name></author><author><name sortKey="Houjou, T" uniqKey="Houjou T">T Houjou</name></author><author><name sortKey="Taguchi, R" uniqKey="Taguchi R">R Taguchi</name></author><author><name sortKey="Fujimoto, T" uniqKey="Fujimoto T">T Fujimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imamura, K" uniqKey="Imamura K">K Imamura</name></author><author><name sortKey="Hishikawa, N" uniqKey="Hishikawa N">N Hishikawa</name></author><author><name sortKey="Sawada, M" uniqKey="Sawada M">M Sawada</name></author><author><name sortKey="Nagatsu, T" uniqKey="Nagatsu T">T Nagatsu</name></author><author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name></author><author><name sortKey="Hashizume, Y" uniqKey="Hashizume Y">Y Hashizume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Galea, A" uniqKey="Galea A">A Galea</name></author><author><name sortKey="Sytnyk, V" uniqKey="Sytnyk V">V Sytnyk</name></author><author><name sortKey="Crossley, M" uniqKey="Crossley M">M Crossley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melo, Rc" uniqKey="Melo R">RC Melo</name></author><author><name sortKey="D Avila, H" uniqKey="D Avila H">H D'Avila</name></author><author><name sortKey="Wan, Hc" uniqKey="Wan H">HC Wan</name></author><author><name sortKey="Bozza, Pt" uniqKey="Bozza P">PT Bozza</name></author><author><name sortKey="Dvorak, Am" uniqKey="Dvorak A">AM Dvorak</name></author><author><name sortKey="Weller, Pf" uniqKey="Weller P">PF Weller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khatchadourian, A" uniqKey="Khatchadourian A">A Khatchadourian</name></author><author><name sortKey="Bourque, Sd" uniqKey="Bourque S">SD Bourque</name></author><author><name sortKey="Richard, Vr" uniqKey="Richard V">VR Richard</name></author><author><name sortKey="Titorenko, Vi" uniqKey="Titorenko V">VI Titorenko</name></author><author><name sortKey="Maysinger, D" uniqKey="Maysinger D">D Maysinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Pk" uniqKey="Chang P">PK Chang</name></author><author><name sortKey="Khatchadourian, A" uniqKey="Khatchadourian A">A Khatchadourian</name></author><author><name sortKey="Mckinney, Ra" uniqKey="Mckinney R">RA McKinney</name></author><author><name sortKey="Maysinger, D" uniqKey="Maysinger D">D Maysinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welte, Ma" uniqKey="Welte M">MA Welte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K Zhang</name></author><author><name sortKey="Sandoval, H" uniqKey="Sandoval H">H Sandoval</name></author><author><name sortKey="Yamamoto, S" uniqKey="Yamamoto S">S Yamamoto</name></author><author><name sortKey="Jaiswal, M" uniqKey="Jaiswal M">M Jaiswal</name></author><author><name sortKey="Sanz, E" uniqKey="Sanz E">E Sanz</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Hui, J" uniqKey="Hui J">J Hui</name></author><author><name sortKey="Graham, Bh" uniqKey="Graham B">BH Graham</name></author><author><name sortKey="Quintana, A" uniqKey="Quintana A">A Quintana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sierra, A" uniqKey="Sierra A">A Sierra</name></author><author><name sortKey="Abiega, O" uniqKey="Abiega O">O Abiega</name></author><author><name sortKey="Shahraz, A" uniqKey="Shahraz A">A Shahraz</name></author><author><name sortKey="Neumann, H" uniqKey="Neumann H">H Neumann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neher, Jj" uniqKey="Neher J">JJ Neher</name></author><author><name sortKey="Neniskyte, U" uniqKey="Neniskyte U">U Neniskyte</name></author><author><name sortKey="Brown, Gc" uniqKey="Brown G">GC Brown</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Eyo, Ub" uniqKey="Eyo U">UB Eyo</name></author><author><name sortKey="Dailey, Me" uniqKey="Dailey M">ME Dailey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tremblay, Me" uniqKey="Tremblay M">ME Tremblay</name></author><author><name sortKey="Paolicelli, Rc" uniqKey="Paolicelli R">RC Paolicelli</name></author><author><name sortKey="Stevens, B" uniqKey="Stevens B">B Stevens</name></author><author><name sortKey="Wake, H" uniqKey="Wake H">H Wake</name></author><author><name sortKey="Bessis, A" uniqKey="Bessis A">A Bessis</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Parkhurst, Cn" uniqKey="Parkhurst C">CN Parkhurst</name></author><author><name sortKey="Yang, G" uniqKey="Yang G">G Yang</name></author><author><name sortKey="Ninan, I" uniqKey="Ninan I">I Ninan</name></author><author><name sortKey="Savas, Jn" uniqKey="Savas J">JN Savas</name></author><author><name sortKey="Yates, Jr" uniqKey="Yates J">JR Yates</name></author><author><name sortKey="Lafaille, Jj" uniqKey="Lafaille J">JJ Lafaille</name></author><author><name sortKey="Hempstead, Bl" uniqKey="Hempstead B">BL Hempstead</name></author><author><name sortKey="Littman, Dr" uniqKey="Littman D">DR Littman</name></author><author><name sortKey="Gan, Wb" uniqKey="Gan W">WB Gan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kettenmann, H" uniqKey="Kettenmann H">H Kettenmann</name></author><author><name sortKey="Hanisch, Uk" uniqKey="Hanisch U">UK Hanisch</name></author><author><name sortKey="Noda, M" uniqKey="Noda M">M Noda</name></author><author><name sortKey="Verkhratsky, A" uniqKey="Verkhratsky A">A Verkhratsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tyurina, Yy" uniqKey="Tyurina Y">YY Tyurina</name></author><author><name sortKey="Poloyac, Sm" uniqKey="Poloyac S">SM Poloyac</name></author><author><name sortKey="Tyurin, Va" uniqKey="Tyurin V">VA Tyurin</name></author><author><name sortKey="Kapralov, Aa" uniqKey="Kapralov A">AA Kapralov</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name></author><author><name sortKey="Anthonymuthu, Ts" uniqKey="Anthonymuthu T">TS Anthonymuthu</name></author><author><name sortKey="Kapralova, Vi" uniqKey="Kapralova V">VI Kapralova</name></author><author><name sortKey="Vikulina, As" uniqKey="Vikulina A">AS Vikulina</name></author><author><name sortKey="Jung, My" uniqKey="Jung M">MY Jung</name></author><author><name sortKey="Epperly, Mw" uniqKey="Epperly M">MW Epperly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, Ct" uniqKey="Chu C">CT Chu</name></author><author><name sortKey="Bayir, H" uniqKey="Bayir H">H Bayir</name></author><author><name sortKey="Kagan, Ve" uniqKey="Kagan V">VE Kagan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cosentino, K" uniqKey="Cosentino K">K Cosentino</name></author><author><name sortKey="Garcia Saez, Aj" uniqKey="Garcia Saez A">AJ Garcia-Saez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, Ct" uniqKey="Chu C">CT Chu</name></author><author><name sortKey="Ji, J" uniqKey="Ji J">J Ji</name></author><author><name sortKey="Dagda, Rk" uniqKey="Dagda R">RK Dagda</name></author><author><name sortKey="Jiang, Jf" uniqKey="Jiang J">JF Jiang</name></author><author><name sortKey="Tyurina, Yy" uniqKey="Tyurina Y">YY Tyurina</name></author><author><name sortKey="Kapralov, Aa" uniqKey="Kapralov A">AA Kapralov</name></author><author><name sortKey="Tyurin, Va" uniqKey="Tyurin V">VA Tyurin</name></author><author><name sortKey="Yanamala, N" uniqKey="Yanamala N">N Yanamala</name></author><author><name sortKey="Shrivastava, Ih" uniqKey="Shrivastava I">IH Shrivastava</name></author><author><name sortKey="Mohammadyani, D" uniqKey="Mohammadyani D">D Mohammadyani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, M" uniqKey="Ren M">M Ren</name></author><author><name sortKey="Phoon, Ck" uniqKey="Phoon C">CK Phoon</name></author><author><name sortKey="Schlame, M" uniqKey="Schlame M">M Schlame</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Konige, M" uniqKey="Konige M">M Konige</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Sztalryd, C" uniqKey="Sztalryd C">C Sztalryd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiam, Ar" uniqKey="Thiam A">AR Thiam</name></author><author><name sortKey="Farese, Rv" uniqKey="Farese R">RV Farese</name></author><author><name sortKey="Walther, Tc" uniqKey="Walther T">TC Walther</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujimoto, T" uniqKey="Fujimoto T">T Fujimoto</name></author><author><name sortKey="Ohsaki, Y" uniqKey="Ohsaki Y">Y Ohsaki</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author><author><name sortKey="Cheng, J" uniqKey="Cheng J">J Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lajoie, P" uniqKey="Lajoie P">P Lajoie</name></author><author><name sortKey="Guay, G" uniqKey="Guay G">G Guay</name></author><author><name sortKey="Dennis, Jw" uniqKey="Dennis J">JW Dennis</name></author><author><name sortKey="Nabi, Ir" uniqKey="Nabi I">IR Nabi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Guijas, C" uniqKey="Guijas C">C Guijas</name></author><author><name sortKey="Perez Chacon, G" uniqKey="Perez Chacon G">G Perez-Chacon</name></author><author><name sortKey="Astudillo, Am" uniqKey="Astudillo A">AM Astudillo</name></author><author><name sortKey="Rubio, Jm" uniqKey="Rubio J">JM Rubio</name></author><author><name sortKey="Gil De Gomez, L" uniqKey="Gil De Gomez L">L Gil-de-Gomez</name></author><author><name sortKey="Balboa, Ma" uniqKey="Balboa M">MA Balboa</name></author><author><name sortKey="Balsinde, J" uniqKey="Balsinde J">J Balsinde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bazan, He" uniqKey="Bazan H">HE Bazan</name></author><author><name sortKey="Bazan, Ng" uniqKey="Bazan N">NG Bazan</name></author><author><name sortKey="Feeney Burns, L" uniqKey="Feeney Burns L">L Feeney-Burns</name></author><author><name sortKey="Berman, Er" uniqKey="Berman E">ER Berman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tremblay, Me" uniqKey="Tremblay M">ME Tremblay</name></author><author><name sortKey="Zettel, Ml" uniqKey="Zettel M">ML Zettel</name></author><author><name sortKey="Ison, Jr" uniqKey="Ison J">JR Ison</name></author><author><name sortKey="Allen, Pd" uniqKey="Allen P">PD Allen</name></author><author><name sortKey="Majewska, Ak" uniqKey="Majewska A">AK Majewska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kennedy, Cj" uniqKey="Kennedy C">CJ Kennedy</name></author><author><name sortKey="Rakoczy, Pe" uniqKey="Rakoczy P">PE Rakoczy</name></author><author><name sortKey="Constable, Ij" uniqKey="Constable I">IJ Constable</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kagan, Ve" uniqKey="Kagan V">VE Kagan</name></author><author><name sortKey="Chu, Ct" uniqKey="Chu C">CT Chu</name></author><author><name sortKey="Tyurina, Yy" uniqKey="Tyurina Y">YY Tyurina</name></author><author><name sortKey="Cheikhi, A" uniqKey="Cheikhi A">A Cheikhi</name></author><author><name sortKey="Bayir, H" uniqKey="Bayir H">H Bayir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bailey, Ap" uniqKey="Bailey A">AP Bailey</name></author><author><name sortKey="Koster, G" uniqKey="Koster G">G Koster</name></author><author><name sortKey="Guillermier, C" uniqKey="Guillermier C">C Guillermier</name></author><author><name sortKey="Hirst, Em" uniqKey="Hirst E">EM Hirst</name></author><author><name sortKey="Macrae, Ji" uniqKey="Macrae J">JI MacRae</name></author><author><name sortKey="Lechene, Cp" uniqKey="Lechene C">CP Lechene</name></author><author><name sortKey="Postle, Ad" uniqKey="Postle A">AD Postle</name></author><author><name sortKey="Gould, Ap" uniqKey="Gould A">AP Gould</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herms, A" uniqKey="Herms A">A Herms</name></author><author><name sortKey="Bosch, M" uniqKey="Bosch M">M Bosch</name></author><author><name sortKey="Ariotti, N" uniqKey="Ariotti N">N Ariotti</name></author><author><name sortKey="Reddy, Bj" uniqKey="Reddy B">BJ Reddy</name></author><author><name sortKey="Fajardo, A" uniqKey="Fajardo A">A Fajardo</name></author><author><name sortKey="Fernandez Vidal, A" uniqKey="Fernandez Vidal A">A Fernandez-Vidal</name></author><author><name sortKey="Alvarez Guaita, A" uniqKey="Alvarez Guaita A">A Alvarez-Guaita</name></author><author><name sortKey="Fernandez Rojo, Ma" uniqKey="Fernandez Rojo M">MA Fernandez-Rojo</name></author><author><name sortKey="Rentero, C" uniqKey="Rentero C">C Rentero</name></author><author><name sortKey="Tebar, F" uniqKey="Tebar F">F Tebar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schonthal, Ah" uniqKey="Schonthal A">AH Schonthal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Begum, G" uniqKey="Begum G">G Begum</name></author><author><name sortKey="Harvey, L" uniqKey="Harvey L">L Harvey</name></author><author><name sortKey="Dixon, Ce" uniqKey="Dixon C">CE Dixon</name></author><author><name sortKey="Sun, D" uniqKey="Sun D">D Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salem, N" uniqKey="Salem N">N Salem</name></author><author><name sortKey="Litman, B" uniqKey="Litman B">B Litman</name></author><author><name sortKey="Kim, Hy" uniqKey="Kim H">HY Kim</name></author><author><name sortKey="Gawrisch, K" uniqKey="Gawrisch K">K Gawrisch</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Schmitz, G" uniqKey="Schmitz G">G Schmitz</name></author><author><name sortKey="Muller, G" uniqKey="Muller G">G Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hariri, M" uniqKey="Hariri M">M Hariri</name></author><author><name sortKey="Millane, G" uniqKey="Millane G">G Millane</name></author><author><name sortKey="Guimond, Mp" uniqKey="Guimond M">MP Guimond</name></author><author><name sortKey="Guay, G" uniqKey="Guay G">G Guay</name></author><author><name sortKey="Dennis, Jw" uniqKey="Dennis J">JW Dennis</name></author><author><name sortKey="Nabi, Ir" uniqKey="Nabi I">IR Nabi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Filomeni, G" uniqKey="Filomeni G">G Filomeni</name></author><author><name sortKey="De Zio, D" uniqKey="De Zio D">D De Zio</name></author><author><name sortKey="Cecconi, F" uniqKey="Cecconi F">F Cecconi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maysinger, D" uniqKey="Maysinger D">D Maysinger</name></author><author><name sortKey="Groger, D" uniqKey="Groger D">D Groger</name></author><author><name sortKey="Lake, A" uniqKey="Lake A">A Lake</name></author><author><name sortKey="Licha, K" uniqKey="Licha K">K Licha</name></author><author><name sortKey="Weinhart, M" uniqKey="Weinhart M">M Weinhart</name></author><author><name sortKey="Chang, Pk" uniqKey="Chang P">PK Chang</name></author><author><name sortKey="Mulvey, R" uniqKey="Mulvey R">R Mulvey</name></author><author><name sortKey="Haag, R" uniqKey="Haag R">R Haag</name></author><author><name sortKey="Mckinney, Ra" uniqKey="Mckinney R">RA McKinney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kress, H" uniqKey="Kress H">H Kress</name></author><author><name sortKey="Stelzer, Eh" uniqKey="Stelzer E">EH Stelzer</name></author><author><name sortKey="Holzer, D" uniqKey="Holzer D">D Holzer</name></author><author><name sortKey="Buss, F" uniqKey="Buss F">F Buss</name></author><author><name sortKey="Griffiths, G" uniqKey="Griffiths G">G Griffiths</name></author><author><name sortKey="Rohrbach, A" uniqKey="Rohrbach A">A Rohrbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tremblay, Me" uniqKey="Tremblay M">ME Tremblay</name></author><author><name sortKey="Marker, Df" uniqKey="Marker D">DF Marker</name></author><author><name sortKey="Puccini, Jm" uniqKey="Puccini J">JM Puccini</name></author><author><name sortKey="Muly, Ec" uniqKey="Muly E">EC Muly</name></author><author><name sortKey="Lu, Sm" uniqKey="Lu S">SM Lu</name></author><author><name sortKey="Gelbard, Ha" uniqKey="Gelbard H">HA Gelbard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattila, Pk" uniqKey="Mattila P">PK Mattila</name></author><author><name sortKey="Lappalainen, P" uniqKey="Lappalainen P">P Lappalainen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heid, H" uniqKey="Heid H">H Heid</name></author><author><name sortKey="Rickelt, S" uniqKey="Rickelt S">S Rickelt</name></author><author><name sortKey="Zimbelmann, R" uniqKey="Zimbelmann R">R Zimbelmann</name></author><author><name sortKey="Winter, S" uniqKey="Winter S">S Winter</name></author><author><name sortKey="Schumacher, H" uniqKey="Schumacher H">H Schumacher</name></author><author><name sortKey="Dorflinger, Y" uniqKey="Dorflinger Y">Y Dorflinger</name></author><author><name sortKey="Kuhn, C" uniqKey="Kuhn C">C Kuhn</name></author><author><name sortKey="Franke, Ww" uniqKey="Franke W">WW Franke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeung, T" uniqKey="Yeung T">T Yeung</name></author><author><name sortKey="Heit, B" uniqKey="Heit B">B Heit</name></author><author><name sortKey="Dubuisson, Jf" uniqKey="Dubuisson J">JF Dubuisson</name></author><author><name sortKey="Fairn, Gd" uniqKey="Fairn G">GD Fairn</name></author><author><name sortKey="Chiu, B" uniqKey="Chiu B">B Chiu</name></author><author><name sortKey="Inman, R" uniqKey="Inman R">R Inman</name></author><author><name sortKey="Kapus, A" uniqKey="Kapus A">A Kapus</name></author><author><name sortKey="Swanson, M" uniqKey="Swanson M">M Swanson</name></author><author><name sortKey="Grinstein, S" uniqKey="Grinstein S">S Grinstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Bx" uniqKey="Huang B">BX Huang</name></author><author><name sortKey="Akbar, M" uniqKey="Akbar M">M Akbar</name></author><author><name sortKey="Kevala, K" uniqKey="Kevala K">K Kevala</name></author><author><name sortKey="Kim, Hy" uniqKey="Kim H">HY Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biden, Tj" uniqKey="Biden T">TJ Biden</name></author><author><name sortKey="Boslem, E" uniqKey="Boslem E">E Boslem</name></author><author><name sortKey="Chu, Ky" uniqKey="Chu K">KY Chu</name></author><author><name sortKey="Sue, N" uniqKey="Sue N">N Sue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, Tw" uniqKey="Jung T">TW Jung</name></author><author><name sortKey="Hwang, Hj" uniqKey="Hwang H">HJ Hwang</name></author><author><name sortKey="Hong, Hc" uniqKey="Hong H">HC Hong</name></author><author><name sortKey="Choi, Hy" uniqKey="Choi H">HY Choi</name></author><author><name sortKey="Yoo, Hj" uniqKey="Yoo H">HJ Yoo</name></author><author><name sortKey="Baik, Sh" uniqKey="Baik S">SH Baik</name></author><author><name sortKey="Choi, Km" uniqKey="Choi K">KM Choi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fredman, G" uniqKey="Fredman G">G Fredman</name></author><author><name sortKey="Ozcan, L" uniqKey="Ozcan L">L Ozcan</name></author><author><name sortKey="Spolitu, S" uniqKey="Spolitu S">S Spolitu</name></author><author><name sortKey="Hellmann, J" uniqKey="Hellmann J">J Hellmann</name></author><author><name sortKey="Spite, M" uniqKey="Spite M">M Spite</name></author><author><name sortKey="Backs, J" uniqKey="Backs J">J Backs</name></author><author><name sortKey="Tabas, I" uniqKey="Tabas I">I Tabas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Pu, H" uniqKey="Pu H">H Pu</name></author><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Leak, Rk" uniqKey="Leak R">RK Leak</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Liou, Ak" uniqKey="Liou A">AK Liou</name></author><author><name sortKey="Hu, X" uniqKey="Hu X">X Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Ma, L" uniqKey="Ma L">L Ma</name></author><author><name sortKey="Ruan, L" uniqKey="Ruan L">L Ruan</name></author><author><name sortKey="Kong, Y" uniqKey="Kong Y">Y Kong</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Wang, Jm" uniqKey="Wang J">JM Wang</name></author><author><name sortKey="Le, Y" uniqKey="Le Y">Y Le</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Titos, E" uniqKey="Titos E">E Titos</name></author><author><name sortKey="Rius, B" uniqKey="Rius B">B Rius</name></author><author><name sortKey="Gonzalez Periz, A" uniqKey="Gonzalez Periz A">A Gonzalez-Periz</name></author><author><name sortKey="Lopez Vicario, C" uniqKey="Lopez Vicario C">C Lopez-Vicario</name></author><author><name sortKey="Moran Salvador, E" uniqKey="Moran Salvador E">E Moran-Salvador</name></author><author><name sortKey="Martinez Clemente, M" uniqKey="Martinez Clemente M">M Martinez-Clemente</name></author><author><name sortKey="Arroyo, V" uniqKey="Arroyo V">V Arroyo</name></author><author><name sortKey="Claria, J" uniqKey="Claria J">J Claria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serhan, Cn" uniqKey="Serhan C">CN Serhan</name></author><author><name sortKey="Petasis, Na" uniqKey="Petasis N">NA Petasis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michaud, Jp" uniqKey="Michaud J">JP Michaud</name></author><author><name sortKey="Halle, M" uniqKey="Halle M">M Halle</name></author><author><name sortKey="Lampron, A" uniqKey="Lampron A">A Lampron</name></author><author><name sortKey="Theriault, P" uniqKey="Theriault P">P Theriault</name></author><author><name sortKey="Prefontaine, P" uniqKey="Prefontaine P">P Prefontaine</name></author><author><name sortKey="Filali, M" uniqKey="Filali M">M Filali</name></author><author><name sortKey="Tribout Jover, P" uniqKey="Tribout Jover P">P Tribout-Jover</name></author><author><name sortKey="Lanteigne, Am" uniqKey="Lanteigne A">AM Lanteigne</name></author><author><name sortKey="Jodoin, R" uniqKey="Jodoin R">R Jodoin</name></author><author><name sortKey="Cluff, C" uniqKey="Cluff C">C Cluff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neher, Jj" uniqKey="Neher J">JJ Neher</name></author><author><name sortKey="Neniskyte, U" uniqKey="Neniskyte U">U Neniskyte</name></author><author><name sortKey="Zhao, Jw" uniqKey="Zhao J">JW Zhao</name></author><author><name sortKey="Bal Price, A" uniqKey="Bal Price A">A Bal-Price</name></author><author><name sortKey="Tolkovsky, Am" uniqKey="Tolkovsky A">AM Tolkovsky</name></author><author><name sortKey="Brown, Gc" uniqKey="Brown G">GC Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, Q" uniqKey="Shi Q">Q Shi</name></author><author><name sortKey="Colodner, Kj" uniqKey="Colodner K">KJ Colodner</name></author><author><name sortKey="Matousek, Sb" uniqKey="Matousek S">SB Matousek</name></author><author><name sortKey="Merry, K" uniqKey="Merry K">K Merry</name></author><author><name sortKey="Hong, S" uniqKey="Hong S">S Hong</name></author><author><name sortKey="Kenison, Je" uniqKey="Kenison J">JE Kenison</name></author><author><name sortKey="Frost, Jl" uniqKey="Frost J">JL Frost</name></author><author><name sortKey="Le, Kx" uniqKey="Le K">KX Le</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Dodart, Jc" uniqKey="Dodart J">JC Dodart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, S" uniqKey="Hong S">S Hong</name></author><author><name sortKey="Beja Glasser, Vf" uniqKey="Beja Glasser V">VF Beja-Glasser</name></author><author><name sortKey="Nfonoyim, Bm" uniqKey="Nfonoyim B">BM Nfonoyim</name></author><author><name sortKey="Frouin, A" uniqKey="Frouin A">A Frouin</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Ramakrishnan, S" uniqKey="Ramakrishnan S">S Ramakrishnan</name></author><author><name sortKey="Merry, Km" uniqKey="Merry K">KM Merry</name></author><author><name sortKey="Shi, Q" uniqKey="Shi Q">Q Shi</name></author><author><name sortKey="Rosenthal, A" uniqKey="Rosenthal A">A Rosenthal</name></author><author><name sortKey="Barres, Ba" uniqKey="Barres B">BA Barres</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kettenmann, H" uniqKey="Kettenmann H">H Kettenmann</name></author><author><name sortKey="Kirchhoff, F" uniqKey="Kirchhoff F">F Kirchhoff</name></author><author><name sortKey="Verkhratsky, A" uniqKey="Verkhratsky A">A Verkhratsky</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Knight, Ra" uniqKey="Knight R">RA Knight</name></author><author><name sortKey="Verkhratsky, A" uniqKey="Verkhratsky A">A Verkhratsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peretti, D" uniqKey="Peretti D">D Peretti</name></author><author><name sortKey="Bastide, A" uniqKey="Bastide A">A Bastide</name></author><author><name sortKey="Radford, H" uniqKey="Radford H">H Radford</name></author><author><name sortKey="Verity, N" uniqKey="Verity N">N Verity</name></author><author><name sortKey="Molloy, C" uniqKey="Molloy C">C Molloy</name></author><author><name sortKey="Martin, Mg" uniqKey="Martin M">MG Martin</name></author><author><name sortKey="Moreno, Ja" uniqKey="Moreno J">JA Moreno</name></author><author><name sortKey="Steinert, Jr" uniqKey="Steinert J">JR Steinert</name></author><author><name sortKey="Smith, T" uniqKey="Smith T">T Smith</name></author><author><name sortKey="Dinsdale, D" uniqKey="Dinsdale D">D Dinsdale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, Jl" uniqKey="Price J">JL Price</name></author><author><name sortKey="Mckeel, Dw" uniqKey="Mckeel D">DW McKeel</name></author><author><name sortKey="Morris, Jc" uniqKey="Morris J">JC Morris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karch, Cm" uniqKey="Karch C">CM Karch</name></author><author><name sortKey="Goate, Am" uniqKey="Goate A">AM Goate</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Dd" uniqKey="Raj D">DD Raj</name></author><author><name sortKey="Jaarsma, D" uniqKey="Jaarsma D">D Jaarsma</name></author><author><name sortKey="Holtman, Ir" uniqKey="Holtman I">IR Holtman</name></author><author><name sortKey="Olah, M" uniqKey="Olah M">M Olah</name></author><author><name sortKey="Ferreira, Fm" uniqKey="Ferreira F">FM Ferreira</name></author><author><name sortKey="Schaafsma, W" uniqKey="Schaafsma W">W Schaafsma</name></author><author><name sortKey="Brouwer, N" uniqKey="Brouwer N">N Brouwer</name></author><author><name sortKey="Meijer, Mm" uniqKey="Meijer M">MM Meijer</name></author><author><name sortKey="De Waard, Mc" uniqKey="De Waard M">MC de Waard</name></author><author><name sortKey="Van Der Pluijm, I" uniqKey="Van Der Pluijm I">I van der Pluijm</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author><author><name sortKey="Shinohara, Y" uniqKey="Shinohara Y">Y Shinohara</name></author><author><name sortKey="Fujimoto, T" uniqKey="Fujimoto T">T Fujimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Butovsky, O" uniqKey="Butovsky O">O Butovsky</name></author><author><name sortKey="Jedrychowski, Mp" uniqKey="Jedrychowski M">MP Jedrychowski</name></author><author><name sortKey="Moore, Cs" uniqKey="Moore C">CS Moore</name></author><author><name sortKey="Cialic, R" uniqKey="Cialic R">R Cialic</name></author><author><name sortKey="Lanser, Aj" uniqKey="Lanser A">AJ Lanser</name></author><author><name sortKey="Gabriely, G" uniqKey="Gabriely G">G Gabriely</name></author><author><name sortKey="Koeglsperger, T" uniqKey="Koeglsperger T">T Koeglsperger</name></author><author><name sortKey="Dake, B" uniqKey="Dake B">B Dake</name></author><author><name sortKey="Wu, Pm" uniqKey="Wu P">PM Wu</name></author><author><name sortKey="Doykan, Ce" uniqKey="Doykan C">CE Doykan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bligh, Eg" uniqKey="Bligh E">EG Bligh</name></author><author><name sortKey="Dyer, Wj" uniqKey="Dyer W">WJ Dyer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><noCountry><name sortKey="Bisht, Kanchan" sort="Bisht, Kanchan" uniqKey="Bisht K" first="Kanchan" last="Bisht">Kanchan Bisht</name><name sortKey="Lecours, Cynthia" sort="Lecours, Cynthia" uniqKey="Lecours C" first="Cynthia" last="Lecours">Cynthia Lecours</name><name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name><name sortKey="Savage, Julie C" sort="Savage, Julie C" uniqKey="Savage J" first="Julie C." last="Savage">Julie C. Savage</name><name sortKey="Titorenko, Vladimir" sort="Titorenko, Vladimir" uniqKey="Titorenko V" first="Vladimir" last="Titorenko">Vladimir Titorenko</name><name sortKey="Tremblay, Marie Eve" sort="Tremblay, Marie Eve" uniqKey="Tremblay M" first="Marie-Eve" last="Tremblay">Marie-Eve Tremblay</name></noCountry><country name="Canada"><region name="Québec"><name sortKey="Zhang, Issan" sort="Zhang, Issan" uniqKey="Zhang I" first="Issan" last="Zhang">Issan Zhang</name></region><name sortKey="Maysinger, Dusica" sort="Maysinger, Dusica" uniqKey="Maysinger D" first="Dusica" last="Maysinger">Dusica Maysinger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000212 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000212 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4879742
|texte= Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27220286" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |